The people most directly affected are human rights defenders, environmental activists, and local communities in the Bajo Aguán region of Honduras, particularly those who oppose mining operations and corruption. This resolution brings international attention to their struggles, threats, and the lack of justice in cases like Juan López's. The families and colleagues of Juan López and other murdered activists would also be affected by this formal recognition and calls for justice.

Additionally, the Honduran government and its judicial system are indirectly affected, as the resolution expresses U.S. congressional support for specific actions, like establishing anti-corruption commissions and an international investigation into López's murder. While not legally binding, it puts pressure on Honduran authorities to address impunity and protect activists. U.S. government agencies, particularly the State Department, are also called upon to increase their engagement and support for human rights efforts in Honduras.