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Controlled Substances Act (CSA)

The main federal law in the U.S. that regulates the manufacture, importation, possession, use, and distribution of certain drugs and chemicals.

Schedule I

The most restrictive category of controlled substances under the CSA, for drugs with a high potential for abuse, no accepted medical use, and a lack of accepted safety for use under medical supervision.

Nitazenes (2-Benzylbenzimidazole opioids)

A class of synthetic (man-made) opioid drugs, some of which are significantly more potent than fentanyl, with no recognized medical use.

Synthetic Opioids

Opioid drugs that are entirely man-made, rather than derived from the opium poppy. Examples include fentanyl and nitazenes.

DEA (Drug Enforcement Administration)

A U.S. federal agency tasked with combating drug smuggling and distribution within the United States.

Class-wide scheduling

A method of controlling drugs by defining an entire group of chemically related substances, rather than listing each individual drug separately, to prevent new variations from circumventing the law.

Mu-opioid receptor