The primary groups affected would be agencies and departments within the U.S. federal government that currently provide or might in the future provide foreign aid or support to El Salvador, particularly any assistance that could directly or indirectly benefit the CECOT prison. This could include the State Department, USAID, and potentially parts of the Department of Defense if they engage in security cooperation that touches on correctional facilities. These entities would need to ensure their funding streams comply with the new prohibition.

Additionally, the government of El Salvador and the administration of the CECOT prison would be affected, as they would no longer receive any U.S. federal financial assistance related to that facility. Organizations or contractors working with the U.S. government on projects in El Salvador might also be impacted if their activities could be construed as supporting the CECOT prison, requiring them to adjust their operations to avoid violating the new law.