SAMDT 4057 — In the nature of a substitute.

AMENDS

AMENDMENT PROGRESS

STEP 3 OF 3

Proposed

Considered

Disposed

Proposed
Considered
Disposed

DISPOSITION

ADOPTED

DEC 16, 2025

“Amendment SA 4057 agreed to in Senate by Unanimous Consent.”

what this changes

This amendment replaces the entire text of the bill with an updated version to ensure the legal language is precise. It maintains the bill's core goal of updating FDA rules to use the term 'nonclinical' instead of 'animal' when describing how new drugs are tested.

WHY IT MATTERS

Substitute amendments are used to fix errors or improve the bill's wording before a final vote. In this case, it ensures the FDA has clear, legally sound instructions for updating its drug-testing regulations.

WHO IS AFFECTED

This primarily affects the FDA and drug researchers, as it clarifies the transition toward modern testing methods that may not involve animals.

AMENDS

S 355PASSED SENATE

FDA Modernization Act 3.0

KEY POINTS

low

Full Text Replacement

By replacing the whole bill, the sponsor ensured that all technical language is consistent and ready for the next stage of the legislative process.

low

Terminology Alignment

It reinforces the shift from 'animal testing' language to 'nonclinical testing,' which includes modern computer models and lab-grown tissues.

GLOSSARY

In the nature of a substitute: An amendment that replaces the entire text of a bill with a new version, rather than just changing a few words.
Unanimous Consent: A situation where no Senator objects to a proposal, allowing it to pass quickly without a formal counted vote.

Official sources

SAMDT 4057 on Congress.gov

This analysis used: Amendment purpose · Amended bill: summary · Latest action

ACTION TIMELINE

6 EVENTS

DEC 16, 25

Amendment SA 4057 agreed to in Senate by Unanimous Consent.

FLOOR

DEC 16, 25

Amendment SA 4057 proposed by Senator Thune for Senator Booker. (consideration: CR S8794) In the nature of a substitute.

FLOOR

DEC 16, 25

INTROREFERRAL

DEC 16, 25

Senate amendment proposed (on the floor): Amendment SA 4057 proposed by Senator Thune for Senator Booker.

FLOOR

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In the nature of a substitute.

AMENDS

SUMMARY

KEY POINTS

SPONSORSHIP

ACTION TIMELINE

AMENDMENT INFO

READER REACTIONS

Discussion

In the nature of a substitute.

AMENDS

AMENDMENT PROGRESS

DISPOSITION

WHY IT MATTERS

WHO IS AFFECTED

KEY POINTS

GLOSSARY

Official sources

ACTION TIMELINE

SPONSORS

READER REACTIONS

What do you think?

Discussion

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In the nature of a substitute.

AMENDS

SUMMARY

KEY POINTS

SPONSORSHIP

ACTION TIMELINE

AMENDMENT INFO

READER REACTIONS

Discussion

In the nature of a substitute.

AMENDS

AMENDMENT PROGRESS

DISPOSITION

WHY IT MATTERS

WHO IS AFFECTED

KEY POINTS

GLOSSARY

Official sources

ACTION TIMELINE

SPONSORS

READER REACTIONS

What do you think?

Discussion